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She needs to find another doctor, while some medication cause more damge than others, her doctor is being nelgigent on her treatment if is is bad enough for you to leave. You do need to do what's best for your kids an yourself, however I would encorage you to help her find another doctor or at least get a second opinion. It's simply not acceptable for her not to have a working treatment with all the treatments and success in patients with her conditions.
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Maybe a family intervention? Or maybe a marriage counselor to help you discuss? I'm really sorry you are going through this :(
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If you do decided to leave her make it clear that her unwillingness is contributing. Perhaps that can be a big wakeup call. You are doing the right thing for your children, I grew up with an unstable parent who still refuses care. It has taken such a toll on me as an adult.

Also have you spoken to her doctor? You can meet with him or call him an tell no the treatment is not working.
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