Talk About Marriage banner

4341 - 4355 of 4355 Posts

·
Premium Member
Joined
·
24,226 Posts
Hey @Ikaika -- I read this today and wondered if you had seen this/had any thoughts.


I know it's not a scientific/medical journal, but I think it makes a lot of sense.

Sent from my SM-G981U using Tapatalk
this makes a lot sense since we know that the target for this virus are any cells that harbors the ACE-2 receptor. One such cells that contain this receptor, endothelial cells. Endothelial cells line the blood vessels and chambers of the heart. So, yea, this is not too surprising.
 

·
Registered
Joined
·
7,009 Posts
this makes a lot sense since we know that the target for this virus are any cells that harbors the ACE-2 receptor. One such cells that contain this receptor, endothelial cells. Endothelial cells line the blood vessels and chambers of the heart. So, yea, this is not too surprising.
My thought was would ACE inhibitors help to slow the progress of the disease?

Sent from my SM-G981U using Tapatalk
 

·
Premium Member
Joined
·
24,226 Posts
My thought was would ACE inhibitors help to slow the progress of the disease?

Sent from my SM-G981U using Tapatalk
Unfortunately, the ACE inhibitor links onto a different domain than the virus to this receptor-enzyme. So, the ACE-inhibitor does not inhibit the S1 domain of the spikes of the coronavirus from linking onto the receptor, it only inhibits the angiotensin I.
 

·
Registered
Joined
·
7,009 Posts
Unfortunately, the ACE inhibitor links onto a different domain than the virus to this receptor-enzyme. So, the ACE-inhibitor does not inhibit the S1 domain of the spikes of the coronavirus from linking onto the receptor, it only inhibits the angiotensin I.
I only understand about 50% of that, but I appreciate the response and your attempt to explain it to me.

I understood the most important part, "Nice thought, but it won't work." I trust that the rest is accurate, because you are a scientist and I am not.

Sent from my SM-G981U using Tapatalk
 

·
Premium Member
Joined
·
24,226 Posts
I only understand about 50% of that, but I appreciate the response and your attempt to explain it to me.

I understood the most important part, "Nice thought, but it won't work." I trust that the rest is accurate, because you are a scientist and I am not.

Sent from my SM-G981U using Tapatalk
Not necessarily the classic ACE-inhibitors, there are some medications related to ACE inhibitors that are being tested to combat this virus. So, your initial instinct was spot on.
 

·
Premium Member
Joined
·
24,226 Posts
There is some new preliminary evidence that SARS-CoV-2 in Europe may have gone through some major mutational events that is rendering this virus less contagious than it first presented itself as in Dec - March.

Nothing has been published on it yet, just noise in the science forums.
 

·
Premium Member
Joined
·
24,226 Posts
If any of you are a fan of audible and interested in the topic of infectious disease, I have a recommendation:

The Great Courses series

”An Introduction to Infectious Diseases” by Professor Barry C Fox
 

·
Registered
Joined
·
2,103 Posts
A trial began today for a therapy(treatment of sick patients) using antibodies. Results on how safe it is are expected by month's end, but apparently they won't know how effective it is until a second phase of testing. It may also be useful for preventing the disease.
 

·
Registered
Joined
·
2,103 Posts
There is some new preliminary evidence that SARS-CoV-2 in Europe may have gone through some major mutational events that is rendering this virus less contagious than it first presented itself as in Dec - March.

Nothing has been published on it yet, just noise in the science forums.
It seems counterintuitive to this lay person that a less contagious version would become more prevalent, but there's probably something I don't understand.
 

·
Premium Member
Joined
·
24,226 Posts
It seems counterintuitive to this lay person that a less contagious version would become more prevalent, but there's probably something I don't understand.
You are referring to Lamarckism, a form of evolution that has long since been an unaccepted theory. This, opposed to the accepted theory of evolution that is based on random mutations that lead to iterations. The iterations that allow for survival of the fitter. Some mutations may lead to a more contagious other mutations, less... it does not mean that this mutational iteration will survive, it is just the one that has been isolated as of late.
 

·
Registered
Joined
·
2,013 Posts
It seems counterintuitive to this lay person that a less contagious version would become more prevalent, but there's probably something I don't understand.
The only goal of a virus is to replicate. The fact that the host may get sick or die is just a side effect. But a virus which is has a lot of negative effects will have trouble surviving because either the host will die too quickly or the community will make changes to hinder people getting infected. The latter is what we saw with the CV19 virus. Whole communities shut down because people were dying and hospitals were overwhelmed, which meant the virus couldn't find hosts and replicate as easily. But if another strain of the virus that doesn't cause as many negative consequences becomes more prevalent, the shutdowns are relaxed, people congregate again, and the virus will have more hosts to infect. So the less contagious version could become more prevalent because society will open up more when that version is the dominant strain in that community.

It's important to realize that it's not a single strain of the virus that is becoming less contagious. Rather, it's that the virus mutates constantly and there new and different strains in the community. The strains which have an optimum rate of infection compared to the negative consequences will be most successful.
 

·
Registered
Joined
·
2,103 Posts
You are referring to Lamarckism,
No, I'm not.
a form of evolution that has long since been an unaccepted theory. This, opposed to the accepted theory of evolution that is based on random mutations that lead to iterations. The iterations that allow for survival of the fitter. Some mutations may lead to a more contagious other mutations, less... it does not mean that this mutational iteration will survive, it is just the one that has been isolated as of late.
My understanding of evolution is based upon random mutations, but it seems like a more contagious version of the virus will be replicated more, leave more descendants and eventually replace the less contagious one.
 

·
Registered
Joined
·
2,103 Posts
The only goal of a virus is to replicate.
Not sure they have any goals, but that is the major part of their survival.
The fact that the host may get sick or die is just a side effect.
Sure.
But a virus which is has a lot of negative effects will have trouble surviving because either the host will die too quickly or the community will make changes to hinder people getting infected. The latter is what we saw with the CV19 virus. Whole communities shut down because people were dying and hospitals were overwhelmed, which meant the virus couldn't find hosts and replicate as easily. But if another strain of the virus that doesn't cause as many negative consequences becomes more prevalent, the shutdowns are relaxed, people congregate again, and the virus will have more hosts to infect. So the less contagious version could become more prevalent because society will open up more when that version is the dominant strain in that community.

It's important to realize that it's not a single strain of the virus that is becoming less contagious.
Do we know this?
Rather, it's that the virus mutates constantly and there new and different strains in the community. The strains which have an optimum rate of infection compared to the negative consequences will be most successful.
If I understand the bolded part correctly, the different strains w/ difft. levels of contagiousness are all present in the same community, which means all will face the same mitigation efforts, or lack thereof, and other factors being the same, the more contagious ones will out-propagate and become more prevalent.
 
4341 - 4355 of 4355 Posts
Top